Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications

Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications.

The ARVO 2009 Summer Eye Research Conference (SERC 2009) on Ophthalmic Drug Delivery Systems was held July 31 and August 1, 2009, at the National Institutes of Health (NIH) in Bethesda, Maryland. The conference provided an opportunity to gather a diverse group of more than 200 experts from both academic ophthalmology and the ophthalmic pharmaceutical industry, including laboratory researchers a...

Biodegradable fumarate-based drug-delivery systems for ophthalmic applications.

The function of a photocrosslinked poly(propylene fumarate) (PPF)/poly(N-vinyl pyrrolidone) (PVP) matrix for the sustained release of three ophthalmic model drugs, acetazolamide (AZ), dichlorphenamide (DP), and timolol maleate (TM), was investigated. The drugs differ in molecular weight and degree of dissociation in aqueous environments; both are parameters that significantly influence drug dif...

Basic Research and Clinical Application of Drug Delivery Systems for the Treatment of Age-Related Macular Degeneration

Controlled Drug Delivery and Ophthalmic Applications

Controlled drug delivery occurs when a polymer is combined with a drug in a such a way that the release profile is predefined. Conventional forms of drug delivery are based on tablets, eye drops, ointments and intravenous solutions. These delivery systems were characterized by an immediate and non controlled kinetics depending essentially on the properties of tissues to absorb drugs.In the last...

Clinical Approaches of Retinal Diseases in Pregnancy

Pregnancy leads to significant changes in the body, which potentially affect the retina. Pregnancy can induce disease such as that seen in hypertensive retinopathy and choroidopathy. It can cause exudative retinal detachments in the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), disseminated intravascular coagulation (DIC), and thrombotic thrombocytopenic purpura (TTP), ...